In the present study, we analyzed 1,539 adult AML patients for the prevalence and prognostic impact of non-ITD mutations in the JMD/TKD1 region of FLT3. We confirm that JMD point mutations and deletions are rare, but recurrent alterations in patients with AML at a frequency in the range of previous estimates (8, 9). The gene discussed is FLT3; the disease is acute myeloid leukemia.