In OSCC patients, the detection rate of ctDNA was higher in saliva as compared to plasma, indicating that salivary ctDNA can be used for OSCC detection (28).. Similarly, p53 mutation in exon 4 codon 63 was detected in saliva of early stage OSCC patients (93.33% of cases, p<0.05) with a similar detection rate as patient tumor samples (29). The gene discussed is TP53; the disease is neoplasm.