IRF5 and asthma: We have previously shown that asthma patients have both more interferon-regulatory factor 5 (IRF5)-positive macrophages, associated with Th1/Th17 inflammation, and CD206-positive macrophages, associated with Th2 inflammation, while having fewer anti-inflammatory interleukin-10 (IL10)-positive macrophages as compared to healthy controls (6, 9).