CD8A and alopecia areata: Although interferon-γ (INF-γ)-secreting CD8+ T cells, promoted by CD4+ T cells, mast cells and dendritic cells, have a central role in the etiopathogenesis of alopecia areata (19), recent research has also pointed out the role of Th2 response, also explaining the association between alopecia areata and atopic dermatitis.