The use of these adjuvants have led to models of allergy to peanut, milk, egg, tree nuts, shellfish, among others, in BALB/c, C3H/HeJ and C57BL/6 mice, demonstrated by the production of allergen-specific IgE, Th2 cytokines and anaphylaxis upon food challenge (9). The gene discussed is IGHE; the disease is allergic disease.