Also, although rOSM/PNE and rAreg/PNE induced production of anti-PNE-specific IgE (Figure 4A), these skin sensitizations were not sufficient for oral PNE-induced anaphylaxis (Figure 3E), suggesting that IL33-mediated signals were required to induce a state for responsiveness to oral PNE-induced anaphylaxis. The gene discussed is IGHE; the disease is anaphylaxis.