ALOX15 and chronic rhinosinusitis with nasal polyps: Recently, a genome-wide association study (GWAS) of patients with CRSwNP across several cohorts showed that a missense variant of ALOX-15, causing a p.Thr560Met alteration and leading to near total loss of 15-LO enzymatic activity was associated with a reduction in the risk of CRSwNP (25).