IGHE and anaphylaxis: An excellent example of home-based reintroduction in infants and preschoolers is the milk ladder for IgE-mediated cow milk allergy, which in a retrospective review of 86 children over a 6-year period showed impressive outcomes with 71 patients (82.5%) having improvement in cow milk tolerance, 26 patients (30.2%) tolerating a normal diet (all dairy products), a high rate of completion (only a further seven patients lost to the program), and no patients experiencing anaphylaxis requiring epinephrine (12).