Increased IL-25 expression in nasal polyps compared to control and CRSsNP was reported in CRS patients from Asian countries such as China, Japan and Korea (81, 83, 85, 91, 92, 101, 102), while no significant upregulation was reported in CRS patients from the United States and Australia (96, 98). The gene discussed is IL25; the disease is Nasal polyposis.