Typical for the type 2 immune response is the increased production of local IgE in association with mucosal eosinophilia (33, 41), as well as the increased mucosal infiltration of B cells with the presence of markers of class switch recombination to IgE in CRSwNP patients (41–43). The gene discussed is IGHE; the disease is chronic rhinosinusitis with nasal polyps.