IGHE and allergic disease: Depending on the impacted segment of the GI tract and corresponding symptoms (Appendix 1), a non-IgE-mediated allergy is classified into the following clinical entities: Food Protein induced Enteropathy (FPE), affecting the small intestine, Food Protein Induced Enterocolitis Syndrome (FPIES) affecting the entire gastrointestinal tract and Food Protein Induced Allergic Proctocolitis (FPIAP) localised to the colon (7).