Also, pentraxin-3 binding to FGF-2 inhibits endothelial cell proliferation in vitro and angiogenesis in vivo (32, 74), suggesting that the beneficial effect of pentraxin-3 in airway remodeling may be also due to the reduction of lung neoangiogenesis, as recently demonstrated in a murine model of fibrosarcoma (104). The gene discussed is PTX3; the disease is fibrosarcoma.