Notably, investigation of this locus in two cohorts—the Childhood Origins of Asthma (COAST) birth cohort and the Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort—found that responses to RV, but not RSV, were associated with 17q21; RV-stimulated PBMCs expressed higher levels of two 17q21 genes, GSDMB and ORMDL3 (141). This evidence concerns the gene GSDMB and asthma.