To date, the use of ovalbumin (OVA) in Balb/c mice to induce the symptoms of allergic asthma, such as airway hyper-reactivity, eosinophilia in lung tissue, systemic allergen-specific immunoglobulin E (IgE), and increased Th2 cytokine production, is a well-accepted model in asthma research. This evidence concerns the gene IGHE and asthma.