Selective ADORA2B antagonists have demonstrated anti-inflammatory effects in an allergic asthma mouse model (38), whereas combined agonism of ADORA2B and glucocorticoid receptors has been shown to induce transcription of anti-inflammatory genes in BEAS-2B cells, a human airway epithelial cell line (39). The gene discussed is ADORA2B; the disease is allergic asthma.