Both P2RY13 and P2RY14 have been associated with asthma by GWAS analysis, while studies in mice showed expression of both receptors is increased following allergen challenge, particularly in airway epithelia, neutrophils and eosinophils, and both receptors are involved in IL-33 release and infiltration of eosinophils into the lung (55). Here, P2RY14 is linked to asthma.