The sensitivity and specificity of the identified significantly differentially regulated proteins were evaluated individually as potential biomarkers to distinguish between DOCK8 and AD using ROC analysis; the frequency plot of these proteins is represented in Figure 3D using the PLS-DA model, the AUC of claspin (Figure 3E), and haptoglobin-related protein (Hrp) (Figure 3F). The gene discussed is HPR; the disease is Alzheimer disease.