DOCK8 and Alzheimer disease: A clear separation and clustering were noted between the DOCK8 deficient vs. Ctrls (R2 = 0.984 and Q2 = 0.971) (Figure 2A) between AD vs. Ctrl groups (R2 = 0.994 and Q2 = 0.964) (Figure 2B), and DOCK8 deficient vs. AD also showed a clear separation (R2 = 0.994 and Q2 = 0.955) (Figure 2C).