In comparison to the controls, the differentially regulated proteins in DOCK8 deficiency and AD vs. Ctrls both showed involvement of pathways related to humoral immune response, inflammatory response, and cellular maintenance and function (score of 42) with the proteins centered around the extracellular-regulated kinase (ERK 1⁄2) and STAT3-signaling pathways in Supplementary Figures 1A, 2A. The gene discussed is STAT3; the disease is Alzheimer disease.