As expected, total IgE levels in both DOCK8-deficient and AD groups were elevated when compared to the Ctrl groups, with patients with DOCK8 deficiency, showing significantly higher serum IgE levels (p < 0.05) compared to patients with AD and Ctrl (5–500 KU/L). This evidence concerns the gene IGHE and hyperinsulinemic hypoglycemia, familial, 4.