IL4 and asthma: In mice, ORMDL3 expression has been shown to be induced by allergen, IL-4 and IL-13 via STAT6 and in bronchial epithelial cells, overexpression of ORMDL3 has been shown to trigger activating transcription factor 6 (ATF6), which has also been implicated in airway remodeling in asthma (80).