The pathophysiology and diagnosis of food associated atopic dermatitis and IgE mediated allergy is much better understood, whereas non-IgE mediated food allergies affecting the gastrointestinal tract are clinically well-described but outside of eosinophilic oesophagitis and food protein induced enterocolitis syndrome the pathophysiology is not that well-established (7, 8). Here, IGHE is linked to allergic disease.