The delayed presentation of food allergy symptoms is very common, with data from the United Kingdom (UK) indicating that almost 60% of children with cow's milk protein allergy present with gastrointestinal symptoms and/or atopic dermatitis and the challenge proven incidence of non-IgE mediated cow's milk allergy in the UK was 0.73% (5, 6). The gene discussed is IGHE; the disease is food allergy.