We have previously reported that almost 70% of our non-IgE mediated cohort had frequent upper respiratory tract infections with Latcham et al. (22) finding that 45% of their food allergic cohort had low IgA levels, with higher levels of low IgA in non-IgE mediated allergies, which may also reflect the younger age of the children. This evidence concerns the gene IGHE and Allergy.