Complications of chronic pBOO are increased risk of infection causing lower urinary tract symptoms (LUTS) through a complex pathophysiological pathway involving nitric oxide guanosine monophosphate and RhoA/Rho-kinase, metabolic syndrome, autonomic hyperactivity, pelvic ischemia, psychological factors, imbalance of sex hormones, and inflammatory pathways [27]. This evidence concerns the gene RHOA and metabolic syndrome.