In human pancreatic adenocarcinoma cells, lipoprotein depletion in the cell culture medium leads to the activation of the HIF-1α pathways, but the addition of LDLs, the main cholesterol transporters in the plasma, inhibits the accumulation of HIF-1α by regulating the activity of PHDs enzymes (52). Here, HIF1A is linked to pancreatic adenocarcinoma.