However, infections with a variant epitope (i.e., other than the prototype NS31073 CVNGVCWTV) as the major sequence were associated with significantly lower percentages of global CD8+ T-cells co-expressing PD-1 and Tim-3 (median 2.2 vs 3.0, P= 0.0054 (Figure 2). This evidence concerns the gene HAVCR2 and infection.