TLR4 and infection: In addition, it was recently reported that the inflammatory response to an infection with L. interrogans serovar Copenhageni strain Firocruz L1-130 in humanized TLR4/MD2 transgenic mice was comparable to the response of congenic wild-type mice expressing mouse TLR4, suggesting that functional human or mouse TLR4 is required to control infection by this strain (50).