IFNB1 and COVID-19: When analysis was performed using the O’Brien method and the functional groupings described in the Methods, we found that groups related to TH2 regulations (IL-4, IL-13, IL-33), cell metabolism (lep, lep-R) and interferons (IFNα, IFNβ, IFNγ) were also predictive of life-threatening COVID-19.