A deleterious role of IL-6 signaling in MS has been further demonstrated in studies in experimental autoimmune encephalomyelitis (EAE) mice where IL-6R blockade prevents the development of EAE in IL-6 sufficient mice (53) and IL-6 -/- mice are resistant to EAE (54, 55). The gene discussed is IL6; the disease is experimental autoimmune encephalomyelitis.