Significant effects were observed for increased IL-6 signaling on risk of MS (IL-6 signaling UK Biobank: OR = 1.14, 95% CI = 1.02-1.27, p = 0.02; IL-6 signaling CHARGE: OR = 1.51, 95% CI = 1.11-2.04, p = 0.01) (Figure 2, Supplementary Table 31 and Supplementary Figure 3). This evidence concerns the gene IL6 and myeloid sarcoma.