Likewise, the effect of higher BMI on MS after adjustment for IL-6 signaling remained, though this direct effect is considerably smaller in effect size and only borderline significant compared to the total effect obtained in the univariable analyses without adjustment for IL-6 signaling (MVMR: OR = 1.16, 95% CI =1.00-1.34, p = 0.046) (Figure 3). This evidence concerns the gene IL6 and myeloid sarcoma.