CD4 and neoplasm: Notably, the present results showed that UCB infiltrated by low CD66bST+ cells and high T cells was associated with the most favorable prognosis, whereas a high infiltration of CD66bST+ cells could reverse the beneficial effects of both CD4+ (Additional File 1: Table S6) and CD8+ T cell (Additional File 1: Table S7) responses in the tumor stroma, which is at least in part due to the immunosuppressive effects of tumor-infiltrating neutrophils on T cells.