First, UCB can be further categorized into two distinct types: 1) NMIBC; and 2) MIBC (44) Although the CD66b+ TAN density was inversely associated with the progression of UCB and maintained its prognostic value in predicting a shorter OS stratified according to tumor stage, there are limited number of matched tissues from patients who progressed from NMIBC to MIBC. The gene discussed is CEACAM8; the disease is neoplasm.