Additionally, various TET-interacting proteins, such as EZH2 (Enhancer of zeste homolog 2), SIN3A (SIN3 transcription regulator family member A), the hematopoietic transcription factor SPI1 and EBF1 (B cell factor 1), may modify the actions of TET proteins; SPI1 (involved in the differentiation of B cells and myeloid lineages) is often deregulated in leukemia and potentially influences mRNA splicing (63). This evidence concerns the gene EZH2 and leukemia.