TSLP and asthma: Recently, tezepelumab, a human monoclonal antibody blocking thymic stromal lymphopoietin (TSLP), an epithelial-cell–derived cytokine which, as an alarmin, plays an early role in the inflammatory cascade in asthma, showed significant reduction of exacerbation rate in non-selected patients with severe asthma, including patients with non-T2 asthma.