On the other hand, as underlined by Hirose et al. in an extensive review about dual effects of IL-22 on airway epithelium, atopic dermatitis models and some murine models of asthma found pro-inflammatory effects of IL-22, with enhanced AHR and airway remodeling (mucus hyperproduction and goblet cell hyperplasia, and smooth muscle cell hyperplasia) (95, 99, 133, 134). Here, IL22 is linked to asthma.