RV-1B (a member of the minor receptor group of RV-A) infection of BALB/c mice or RV-16 (RV-A, a member of the major receptor group) infection of mouse-human ICAM-1 transgenic mice induces viral replication in airway epithelial cells, airway inflammation (neutrophilia and lymphocytosis), mucin secretion, and increased IFNs response, similarly to human RV infection (149). This evidence concerns the gene ICAM1 and infection.