Clinical evidence supports the pathogenic role for IgE and mast cells in asthma and RV-induced asthma exacerbation: mast cells are increased in the airway epithelium (30) and within the smooth muscle layer (31–33) in allergic asthma, and in the alveolar parenchyma of uncontrolled allergic asthma (34). Here, IGHE is linked to asthma.