IGHE and Increased total eosinophil count: Mice sensitized and challenged with A. fumigatus conidia develop allergic pulmonary inflammation and AHR with elevated serum IgE and pulmonary IL-4 (177), inhalation of Aspergillus-associated proteases by naïve mice promotes airway eosinophilia through protease-activated receptor-2 engagement (178), and chitin promotes eosinophil recruitment (179, 180).