Mice treated with PBS, PLG(PBS), or PLG(PE) NPs (Figure 3A) did not show evidence of anaphylaxis as measured by core body temperature (Figure 3B) or MCPT-1 release in serum (Figure 3C); however, an equivalent dose (25.75 μg) of soluble PE in PBS did cause significant allergic reactions, as evidenced by temperature decrease and MCPT-1 release, demonstrating the ability of PLG(PE) to mask allergen to avoid reactivity in allergic individuals. Here, CPT1B is linked to anaphylaxis.