SERPING1 and hereditary angioedema: Hereditary angioedema (HAE) due to C1-inhibitor (C1-INH) deficiency (C1-INH-HAE) is a rare autosomal dominant disorder, characterized by recurrent, unpredictable, nonpitting edematous symptoms involving the subcutaneous and/or submucosal tissues and showing intra- and interindividual variability.