It has not escaped our attention that the presumably causal link between HMB and the suppression of the HIF‐1α and PGE2 signaling pathways in endometrium due to increased tissue stiffness resulting from increased lesional fibrosis may also exist for other disorders that cause HMB, such as uterine fibroids and polyps. The gene discussed is HIF1A; the disease is uterine corpus leiomyoma.