CASP3 and cancer: Furthermore, silver was reported to induce apoptosis in cancer cells via ROS formation, increased caspase-3 and p53 activation and lipid peroxidation [42].Initially, the influence of degrading (Mg, Mg–6Ag) and non-degrading (Ti–6Al–4V) material on the progression of tumor and healthy cells in coculture as well as in monocultures under normoxia and hypoxia was studied.