Compared to the PBS and free SR717 groups, the SR717@RGE-HFn NP group exhibited 4.57- and 1.94-fold increases in the number of tumor-infiltrating CD3+ T cells and 2.02- and 9.56-fold increases in the number of CD3+CD8+ T effector cells, respectively (Fig. 6G and H). This evidence concerns the gene CD8A and neoplasm.