The durable accumulation of SR717 within the glioma tumor microenvironment (TME) resulted in the induction of a local innate immune response, as indicated by the significantly upregulated expression of STING signaling-related proteins, elevated mRNA levels of proinflammatory cytokines, and improved recruitment of CD8+ T cells, NK cells and DCs into the tumor tissue. Here, STING1 is linked to neoplasm.