In hepatocellular carcinoma, miR-139-5p can regulate the proliferation, migration and invasion of hepatocellular carcinoma cells by targeting different targets such as SLITRK4 (Wu et al.,2020), CCT5 (Xu et al.,2021) and ARF6 (Wu et al.,2021). The gene discussed is ARF6; the disease is hepatocellular carcinoma.