SMAD5 and hepatocellular carcinoma: The results showed that miR-139-5p and TGFBR3 were significantly down-regulated in hepatocellular carcinoma tissues, and miR-582-3p, ACVR2B, SMAD2 and SMAD5 were up-regulated in hepatocellular carcinoma tissues (Figure 5A; Figure 5B).