We selected 2 differentially expressed miRNAs (miR-139-5p and miR-582-3p) and four hub mRNAs (ACVR2B, SMAD2, SMAD5, and TGFBR3) for qRT-PCR verification in 20 hepatocellular carcinoma tissues and 20 adjacent tissues (Supplementary Material S1). This evidence concerns the gene SMAD2 and hepatocellular carcinoma.