GPC3 and hepatocellular carcinoma: Although several biomarkers have been reported relating to the diagnosis and prognosis of HCC, such as alpha-fetoprotein lens culinaris agglutin-3 (AFP-L3), des-γ-carboxy prothrombin (DCP), glypican-3 (GPC3), and so on, their practical applications are yet to be evaluated (Piñero et al., 2020).