In the current study, the 6 hub genes (IER5, NFKBIZ, CITED2, TNF, SERTAD1, ADM) appeared in module saddlebrown were among the 12 differentially expressed genes identified in Savitz et al. (2013) This indicates that a significant proportion of differentially expressed genes related to mood disorder may be tightly co-regulated, functionally related, or in the same pathway. This evidence concerns the gene TNF and mood disorder.