As a proof-of-concept, we chose to target SYNE4, a gene that encodes nuclear membrane protein nesprin-4 and is associated with hearing loss (Horn et al., 2013), EMX1 associated with neurodevelopmental and infertility disorders (Zhang et al., 2019), (Kim et al., 2010), and SNCA associated with neurodegenerative Parkinson’s Disease (Spillantini et al., 1997), (Bonini and BI, 2005). Here, SYNE4 is linked to infertility disorder.