AKT1 and posterior cortical atrophy: We have discovered a selective PIP5K1α inhibitor, ISA-2011B, that inhibits PIP5K1α kinase activity and blocks its downstream PI3K/AKT phosphorylation, leading to reduced growth and invasion of PCa in cell lines and xenograft mouse models (Semenas et al., 2014; Sarwar et al., 2016; Mandel et al., 2018; Karlsson et al., 2020; Larsson et al., 2020).