As a key proteolytic enzyme, MMP9 produced by cancer cells and extracellular matrixes (ECMs) surrounding the tumor can activate angiogenic factors such as VEGF, leading to increased angiogenesis and metastatic activities (Coussens et al., 2000; Giraudo et al., 2004; Overall and Kleifeld, 2006). This evidence concerns the gene VEGFA and cancer.