Consistently, the inhibitory effect of ISA-2011B on PCa is accompanied with its ability to significantly down-regulate the elevated expression of AR, MMP9 and VEGFR2 (Drake and Huang, 2014; Flemming, 2014; Semenas et al., 2014; Sarwar et al., 2019). This evidence concerns the gene MMP9 and posterior cortical atrophy.