Among them, six DEMDGs (LCP2, PPP1R18, APOL1, FMNL1, NMI, and SHC1) were upregulated in both RCC cells, combined with Supplementary Figure S3; their high expression was associated with poor survival, considering that they might play a role as proto-oncogenes. The gene discussed is APOL1; the disease is renal cell carcinoma.