NEFL and Spinocerebellar ataxia type 3: The observation that CSF NFL and plasma polyQ-ATXN3 levels are elevated in our Q84 mouse model compared to the Q28 controls is in accordance with what we and others have observed in SCA3 patient samples, and with a previous study that looked at NFL levels in cerebellar extracts from SCA3 mice (Costa et al., 2020).