ATXN3 and cerebellar ataxia: It is worth noting, however, that Purkinje cell loss, while occasionally observed (Scherzed et al., 2012), is not as prominent in SCA3 as it is in other spinocerebellar ataxias (Sachdev et al., 1982; Yuasa et al., 1986; Takiyama et al., 1994; Durr et al., 1996).