NOP56 and amyotrophic lateral sclerosis: AAV technology has been used to generate mouse models of other neurodegenerative diseases, including C9orf72-associated amyotrophic lateral sclerosis (ALS) (Chew et al., 2015; Chew et al., 2019), Alzheimer’s disease (Ittner et al., 2019), Huntington’s disease (Maxan et al., 2020) and SCA36 (Todd et al., 2020), and these models successfully recapitulate disease features.