AAV technology has been used to generate mouse models of other neurodegenerative diseases, including C9orf72-associated amyotrophic lateral sclerosis (ALS) (Chew et al., 2015; Chew et al., 2019), Alzheimer’s disease (Ittner et al., 2019), Huntington’s disease (Maxan et al., 2020) and SCA36 (Todd et al., 2020), and these models successfully recapitulate disease features. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.