While variants in this gene did not show strong evidence of genetic association with the traits analyzed here, it is noteworthy that SMOC1 was recently nominated as a novel AD biomarker in proteomic screens of AD CSF and brain samples in various studies (Bai et al., 2020; Wang et al., 2020; Sathe et al., 2021). The gene discussed is SMOC1; the disease is Alzheimer disease.