Rather than the role of BACE1 and the regulatory function of BACE1-AS on amyloidogenic process clearly involved in the pathogenesis of particularly neurodegenerative diseases discussed earlier, both BACE1 and BACE1-AS have been reported with dysregulation in a number of other diseases, which can’t be easily associated with the amylogenic processes. Here, BACE1 is linked to neurodegenerative disease.