An impairment in NGF signaling may therefore support the “small-fiber neuropathy” described in humans (Sima 2003; Ebenezer and Polydefkis 2014), while a VEGF signaling impairment may affect angiogenesis (Okonkwo et al. 2020), and both of these factors may be responsible for delayed wound healing in diabetic mice. This evidence concerns the gene NGF and neuropathy, small fiber.