A transient pharmacological activation of the PI3K-Akt-mTOR signaling axis has been considered a novel clinical intervention strategy to accelerate wound (ulcer) healing (Squarize et al. 2010), and we recently demonstrated that the pro-healing effect of a mutated form of rhNGF includes Akt regulation (Giuliani et al. 2020). This evidence concerns the gene MTOR and ulcer disease.