Seresini et al. (2007) reported that T-bet-positive cells infiltrating the lesion were associated with better clinical outcomes following surgical treatment of HSIL (Seresini et al. 2007), and there are several reports of HMGB1 over-expression in cervical cancer (Hao et al. 2008; Pang et al. 2014). Here, HMGB1 is linked to cervical cancer.