Interestingly, a study in melanoma cells suggested that PAK1 regulated invadopodia formation (Ayala et al., 2008), intriguingly via the same Ser113 phosphorylation site as Moshfegh and colleagues reported, sparking debate over whether PAK1-regulation of invadopodia actin dynamics is cancer-type specific. The gene discussed is PAK1; the disease is melanoma.