The supernatants of in vitro cultured IDH1-mutant glioma cells are thus suspected to contain less CXCL10 compared with those of IDH1-WT glioma cells; this hypothesis is validated by a Boyden chamber assay showing that CD8+ T cell chemotaxis is roughly 3.5-fold less when T cells are chemotaxing toward the supernatant of IDH1-mutant glioma cells (93). This evidence concerns the gene IDH1 and central nervous system cancer.