This patient (also included in group B) had a heterozygous mutation in CFI combined with risk haplotypes in CFH and MCP. Only this patient underwent kidney biopsy, which disclosed a membranoproliferative glomerulonephritis type I. From this group, 4/15 (27%) patients, kept renal replacement therapy dependence after the acute phase and all of them underwent kidney transplantation (KT). Here, CFH is linked to immunoglobulin-mediated membranoproliferative glomerulonephritis.