We further assessed the activation of the unfolded protein response (UPR) upon inhibition of VCP in THP-1, a AML cell line with wild-type fms-like tyrosine kinase 3 (FLT3), and MV4-11, a cell line carrying an FLT3-internal tandem duplication (ITD) mutation. The gene discussed is FLT3; the disease is acute myeloid leukemia.