Re-occurring genetic alterations identified in AML are mutations in components of the signal transduction (e.g. FLT3, KIT, KRAS, NRAS), nulceophosmin-1 (NPM1), myeloid transcription factors, chromatin modifiers, tumor suppressors (e.g. TP53, WT1) and genes associated with DNA methylation (e.g. TET1, TET2, IDH1, IDH2, DNMT3B, DNMT1, DNMT3A) as well as gene fusions involving transcription factors. This evidence concerns the gene FLT3 and acute myeloid leukemia.