CXCL8 and COVID-19: In addition, increased levels of proinflammatory cytokines and pyrogenic substances including IL-6, IL-8, IL-1β, and PGE2 were detected in patients with severe COVID-19 where they were proposed to play a role in recruitment of leukocytes including monocytes and neutrophils to the site of high viral replication in the lungs and subsequently contribute to ARDS [8–10].